Part 1: What are PFAS and How are They Analyzed?
Wednesday, April 23rd, 2025 at 1:00PM-1:30PM ET
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Due to their widespread use and persistence in the environment, the determination of PFAS in various matrices, including water, has become one of the most pressing environmental and human health topics of recent years. The first part of this webinar series introduces PFAS, discusses why we are interested in monitoring them and introduces methods that can be used for their analysis, with a focus on LC-MS.
Part 2: Analytical Challenges and Developing LC-MS Methods for PFAS
Wednesday, May 21st, 2025 at 1:00PM-1:30PM ET
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LC-MS/MS is firmly established as a key analytical technique used to assess the prevalence of PFAS in natural and human environments. The analysis is challenging, due to the low detection limits required, while their ubiquitous use in many materials means that special instrumental considerations are required to prevent background interference. This webinar discusses some of the key considerations when developing LC-MS PFAS methods, including use of a delay column, sample preparation approaches and sample injection considerations. Finally, a series of example PFAS applications are discussed.
Part 3: Tackling and Controlling Background Laboratory PFAS
Thursday, June 26th, 2025 at 1:00PM-1:30PM ET
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The widespread use of PFAS compounds in human environments extends into the laboratory environment, with many materials, equipment and consumables potentially containing extractable PFAS components. This creates a high potential for sample contamination during collection and processing. To avoid quantification issues, it is essential to characterize potential sources of contamination and to apply rigorous working practices to eliminate them. The final part of this webinar series draws on experience and challenges encountered in our own lab from setting up targeted LC-MS/MS methods for the analysis of PFAS in water samples. It and aims to provide guidance to analysts new to, or in the initial stage, of implementing PFAS analysis and will cover topics including potential sources of contamination in the lab, how to test for it and guidance on selecting equipment, consumables and reagents to optimize quantitative method performance.
About the Presenter:
Matt James is a Senior Research Scientist at Avantor Sciences. Matt gained his PhD at University of Bristol and over the last 15 years, he has worked within the Technical Support, Applications and R&D teams within Hichrom, now part of Avantor. Recent focuses have been HPLC/UHPLC method transfer and translation, the use of solid core phases, development of next generation LC stationary phases and the development of LC methods for key applications, such as the analysis of nitrosamines and PFAS by LC-MS/MS.
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