With the worldwide concern about the ubiquitous presence of pollution and unhealthy levels of chemicals in the environment, the urgent need for monitoring and measuring these in multiple matrices is undeniable. For its part, the EPA has developed, validated and published several LC methods for PFAS and PAH analysis. PFAS analysis can be a challenge for chemists because there are PFAS compounds present in LC systems which can interfere with accurate quantitation, especially at low ppt levels. To combat this, a delay column is recommended to prevent PFAS contamination from coeluting with analyzed samples. Improvements in environmental separations are enabled by utilizing Fused-Core® columns.