Liquid chromatography (LC) is a powerful technique for the separation, identification, and quantification of target analytes in complex media such as biomatrices. LC offers target assay flexibility, multiple detection modes, and can be highly automated — all of these are ideal features to be applied to the analysis of high sample numbers or for research purposes in the modern clinical laboratory.
With the introduction of ever-more-powerful and easier-to-use mass spectrometry (MS) detectors at an affordable price point, LC-MS has become increasingly influential as a routine, investigative tool for clinical testing, therapeutic/dose monitoring, and the screening of disease states including quantitative and qualitative biomarker profiling.